Epigenetics and chromatin regulatory proteins in Drosophila
Epigenetics can be defined as non-genetic changes in cellular phenotype that are transmitted through cell-divisions. Epigenetic patterns of histone modifications contribute to the maintenance of cell- and tissue-specific gene expression. They are therefore important for maintenance of specific cell identities and have been implicated in human disease, most prominently in cancer.
In this project, genetic and genomic analyses of chromatin and its regulators will be performed in Drosophila melanogaster to study transcription and formation of epigenetic chromatin states. These studies of chromatin and its regulators by the outstanding repertoire of experimental manipulations available in Drosophila should provide important insights into cell differentiation, proliferation and the mechanisms of carcinogenesis. The project involves molecular, genetic and genomic approaches and experience with molecular cloning, Chromatin immunoprecipitation (ChIP), high-throughput sequencing, and fly genetics is desirable.
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The position is fully funded through the Department.
Boija A, Mahat DB, Zare A, Holmqvist PH, Philip P, Meyers DJ, Cole PA, Lis JT, Stenberg P, Mannervik M (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Molecular Cell, 68, 491-503.
Boija A and Mannervik M (2016). Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan. Proc Natl Acad Sci U S A, 113(31):8735-40.