About the Project
The advertised PhD project carried out in my lab will thus focus on determining the genetic and epigenetic mechanisms controlling epigenetic switches, and on the understanding of their effects on plant plasticity and evolution. As part of the project, existing and newly generated genomics and data will be used to characterize the players involved in controlling epigenetics, and the final aim of the project is to transfer the new findings into crop plants to exploit their use in agriculture.
The proposed project can focus in one of these areas:
1- Explore the links between genome stability and evolution, investigating how epigenetics affect genome plasticity, which directly controls the speed of genome evolution.
2- Investigate the bases of epigenetic variation, studying how epialleles (= genes with identical DNA sequence but different epigenetic marks) are generated, and which factors control their stability.
3- Study the consequences of Transposable element (TE) mobilization.
The aim of this approach is to discover, characterize and investigate the role of active TEs in plants, going beyond the concept of a single reference genome.
Lisch, D. (2013). How important are transposons for plant evolution? Nat. Rev. Genet. 14, 49–61. Philippsen, G.S., et al. (2016). Distribution patterns and impact of transposable elements in genes of green algae. Gene 594, 151–159.
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