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  Epigenomic transcriptomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases


   School of Life Sciences

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  Dr HM Knight  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

This project aims to use high throughput sequencing technologies and molecular approaches to understand how RNA epitranscriptomic processes contribute to susceptibility to human disorders of the brain.

The project will use a combination of bioinformatics and statistical tools with molecular biology techniques to investigate how sequence variants, epigenomic processes and RNA modification profiles differ between populations of healthy and non-healthy individuals. Identified risk variants, epi-alleles and modified transcripts may also be assessed for correlations with phenotypic data such as cognitive performance and biochemical measures. The findings of such studies should improve our understanding of how genetic architecture relates to biological and pathophysiological processes which contribute to expression of brain disease.

Biological Sciences (4) Medicine (26)

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 About the Project