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Epigenomics of neurological disorders


Project Description

Despite increased recognition of links between neurodevelopment defects and early/late onset neurological diseases, underlying molecular mechanisms still remain poorly understood. Our preliminary observations have discovered that non-coding variants linked to brain disorders are enriched in genomic regions that exhibit epigenetic state hallmark of enhancer elements in foetal as well as adult human brain. We next aim to identify and characterize the influence of these nucleotide variations on enhancer function, transcriptional regulation and role of associated gene(s). Hence, we will shortlist some of our identified regions based on significance and establish their enhancer activity and find transcription factors whose binding might be influenced by enhancer SNPs. To reveal target genes under control of these enhancer elements, we will computationally identify expression quantitative trait loci (eQTL) genes and nearest genes of enhancer SNPs and experimentally evaluate the effect of distal genetic variation on gene expression. Since these studies will employ a highly multidisciplinary approach combining Computational Biology, Systems Biology, Genomics, Epigenetics and Neurobiology, it will create an excellent training opportunity for the Ph.D. student in a cutting-edge and promising field of research. For more details, please visit http://www.tiwarilab.com.

ENTRY REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/

Funding Notes

*FUNDING CONFIRMED – Department for the Economy (DfE) Award*

Eligibility for both fees (£4,327 for 2019/20, 2020/21 TBC) and maintenance (£15,009 for 2019/20, 2020/21 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: View Website

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CEM/

When applying, please choose 'MEDICINE' as your subject area/School.

Website for further details about the Lab:
https://pure.qub.ac.uk/en/persons/vijay-tiwari
www.tiwarilab.com

Related Subjects

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