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EPSRC iCASE Studentship – Understanding Skin Permeation of Agrochemicals using Mass Spectrometry Imaging

  • Full or part time

    Prof C J Roberts
  • Application Deadline
    Friday, October 18, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Application are invited for a PhD studentship supported by the EPSRC and Syngenta to work towards developing an improved understanding of skin permeation mechanisms of agrochemicals.

Established methodologies of assessing skin permeation only provide an insight into overall delivery through skin, more recent work undertaken at The University of Nottingham has demonstrated that imaging mass spectrometry techniques can elaborate on this to better understand the delivery of active agents within skin tissue and demonstrate their localisation. This project aims to utilise these techniques to further the understanding of the uptake of agrochemical components through skin highlighting routes of permeation and mechanisms of delivery. The findings from this project will enable product development at Syngenta and ultimately reduce the risks of exposure to agrochemical users.

The applicant will work within an established skin permeation group at the University of Nottingham utilising unique state of the art facilities such as the 3D OrbiSIMS (https://www.nottingham.ac.uk/nmrc/facilities/orbisims/orbitrap-sims.aspx) to provide previously unavailable insight into the permeation of agrochemicals into skin as well as their impact upon the permeability of each other’s permeation characteristics.

Applicants should have (or expect to obtain by the start date) at least a 2.1 degree in Pharmacy, Chemistry, Physics, Life Sciences or another relevant Physical Science. This PhD project will be multidisciplinary, encompassing Franz cell permeation analysis, chemistry of agrochemical agents, mass spectrometry and associated data analytics. The successful candidate should have the following skills:

o Strong analytical skills (to be applied to skin permeation and mass spectrometry)
o Independence and self-motivation
o An ability to work independently and in a team
o A strong aptitude for working with industrial partners
o A high level of proficiency in English
o An excellent work ethic and commitment to the job
o Experience in or knowledge of skin permeation and / mass spectrometry would be advantageous.

Funding Notes

EPSRC iCASE studentships are fully-funded (fees and maintenance) for UK students or provide fees only for EU students from outside the UK

How good is research at University of Nottingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?
Pharmacy

FTE Category A staff submitted: 44.10

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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