Evaluating novel bioactive materials for bone cancer treatment
Survival for bone cancer patients is poor despite the aggressive combined use of surgery, chemotherapy, and/or radiotherapy. If the cancer recurs at the original site prognosis is extremely poor. To improve clinical outcomes, novel therapeutic materials are required.
This PhD project aims to develop and characterise new bioactive materials to improve clinical outcomes for patients suffering from bone cancer. The developed materials will provide a control release of key metal ions to selectively induce tumour cell death and simultaneously stimulate grow new bone.
Recently our group have developed very promising synthetic bioactive materials. This studentship will undertake a series of in-vitro and in-vivo studies to fully characterise these materials with the aim of developing and optimising materials for human applications. The project will involve working with human osteoblasts and mesenchymal stem cells and with established animal models.
Person Specification Applications are invited from ambitious, self-motivated scientists to develop and characterise novel materials for bone cancer applications. Applicants with a keen interest in cell biology, cancer studies, tissue engineering, regenerative medicine, as well as (bio)chemical engineers interested in developing assays for screening the effect of gallium doped bioactive glasses on human osteoblasts and stem cells are particularly encouraged to apply.
The successful applicant should have a first class or upper second class honours degree or equivalent qualification in biological sciences. Preferred skill requirements include knowledge/ experience of cellular, molecular or cancer biology and material science
Contact information For formal enquiries about this project contact Dr Richard Martin by email at [Email Address Removed]
Submitting an application Details of how to submit your application, and the necessary supporting documents can be found here: https://www2.aston.ac.uk/eas/research/prospective-research-students/how-to-apply
Applications must also be accompanied by an outline of the research area, giving an overview of the main themes of the research as detailed in the Background to the Project section above. This should demonstrate your understanding of the research area, how you expect the research to be conducted and an overview of the potential experiments.
If you require further information about the application process please contact the Postgraduate Admissions team at [Email Address Removed]
This studentship includes a fee bursary to cover the home/EU fees rate, plus a maintenance allowance of £14,777 in 2018/19 (subject to eligibility).
Overseas Applicants - This studentship includes a fee bursary to cover the home/EU fees rate plus a maintenance allowance of £14,777 in 2018/19.
Applicants from outside the EU may apply for this studentship but will need to pay the difference between the ‘Home/EU’ and the ‘Overseas’ tuition fees, currently this is £12,290 in 2018/19. As part of the application you will be required to confirm that you have applied for, or, secured this additional funding.