Pathogenic variants in the human KCNT1 gene, which encodes a neuronal sodium-activated potassium channel, cause severe and drug-resistant childhood epilepsy. We have identified novel pharmacological modulators of the KCNT1 potassium channel (Cole et al., 2020), which could be developed into therapeutics. With collaborators at the MRC Mary Lyon Centre, we have developed a mouse model of the disorder using CRISPR/Cas9 gene editing to harbour an epilepsy-causing genetic variant equivalent to that in human patients.
The aim of the project is to determine the effects of novel pharmacological inhibitors of KCNT1 potassium channels, most importantly their potential for reducing seizure activity and other symptoms associated with KCNT1 epilepsy. Modulators will be assessed using cellular electrophysiological assays and evaluated for therapeutic action using the mouse model, by using a combination of cutting-edge optogenetic imaging and behavioural analysis techniques.
The project is available immediately and is fully funded by Epilepsy Research UK. It would suit a candidate with an interest in drug discovery and the utilisation of animal models of neurological disease.
The postgraduate researcher will benefit from the excellent research environment at Leeds, as well as the interdisciplinary nature of this project.
Eligibility
Applicants should have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. A Masters degree is desirable but not essential.
The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.
How to apply
To apply for this scholarship opportunity applicants should complete an online application form and attach the following documentation to support their application.
- a full academic CV
- degree certificate and transcripts of marks
- Evidence that you meet the University's minimum English language requirements (if applicable)
To help us identify that you are applying for this scholarship project please ensure you provide the following information on your application form;
- Select PhD in Biological Sciences as your programme of study
- Give the full project title and name the supervisors listed in this advert
- For source of funding please state you are applying for an advertised Faculty Scholarship
As an international research-intensive university, we welcome students from all walks of life and from across the world. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education. Within the Faculty of Biological Sciences we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community, people who identify as LGBT+; and people with disabilities. Applicants will always be selected based on merit and ability.
For further information about this scholarship please contact the Faculty Graduate School
e: [Email Address Removed]
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