About the Project
This project will build on these findings and our group previous work on the role of the endocannabinoid system in cancer associated bone disease, and will evaluate whether natural and novel tumour-selective synthetic cannabinoid agents affect the ability of melanoma cells to grow, move and influence the function of immune cells in the tumour microenvironment in vitro and ex vivo and in preclinical mouse models.
If successful, the findings of this research will have translational potential in identifying whether topical application of natural or synthetic cannabinoids - in combination with immunotherapy – are of value for the management of metastatic melanoma. Guided by these preclinical studies, we plan to conduct clinical trials to test the effects of CBD and an appropriate novel tumour-selective cannabinoid in advanced melanoma patients (in collaboration with Sarah J Danson, professor and Consultant of Medical Oncology, University of Sheffield).This addresses an unmet clinical need, as metastasis and acquired resistance to conventional anti-cancer therapy are clinical problems in advanced melanoma patients.
Candidates must have a first or upper second class honors degree. Laboratory hands-on experience in tissue culture techniques is desirable. Experience with transfection techniques and in vivo imaging would be advantageous.
Dr Aymen Idris, [email protected], Tel: 00441142713338.
How to apply:
Please complete a University Postgraduate Research Application form available here: View Website
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