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Evidence-based healthcare in the prevention of oral mucositis


   Faculty of Biology, Medicine and Health


About the Project

Oral mucositis is characterised by painful ulcers of the mouth and is a side effect of some cancer treatments. Typically, it can affect over 75% of high risk patients (Scully, 2006) causing severe pain and difficulty with eating and drinking that may necessitate pain relief treatment and nasogastric or intravenous feeding. Mucositis is therefore a condition which can have substantial impact on quality of life and further compounds the suffering of cancer patients. At present, there is no known standard of care for the prevention of oral mucositis. It is therefore important to establish the evidence base around how best to prevent patients undergoing cancer treatment from developing mucositis. A programme of work is ongoing to develop this evidence base and this PhD project would contribute to this.

The methodological focus of this project is on evidence synthesis and the student would become experienced in systematic review methods. Additionally there will be scope for the developing the project to incorporate mixed methods including qualitative work around the implementation of evidence. 

Through undertaking this project, the student will become experienced in gold standard systematic review methods, it may also be possible to develop this project to incorporate mixed methods including qualitative investigation. There may also be scope working with guideline development bodies. 

Areas of skills and training that could be gained:

•             Gold standard systematic review methods

•             Statistical training with emphasis on meta-analysis

•             Design of mixed methods research

•             Survey design

•             Qualitative interviewing and analysis

•             Critical appraisal of guidelines

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience, particularly in cell culture and molecular biology, are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Genetics

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk


Funding Notes

Applications are invited from self-funded students. This project has a Band 1 fee. Details of our different fee bands can be found on our website (View Website).
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website

References

Riley P, Glenny AM, Worthington HV, Littlewood A, Clarkson JE, McCabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochrane Database of Systematic Reviews 2015, Issue 12. Art. No.: CD011552. DOI: 10.1002/14651858.CD011552.pub2.
Riley P, Glenny AM, Worthington HV, Littlewood A, Fernandez Mauleffinch LM, Clarkson JE, McCabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. Cochrane Database of Systematic Reviews 2017, Issue 11. Art. No.: CD011990. DOI: 10.1002/14651858.CD011990.pub2.
Scully C, Sonis S, Diz PD. Oral mucositis. Oral Diseases 2006;12(3):229‐41.

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