Exercise and biomarkers of cardiovascular disease/type 2 diabetes risk in black, Asian and minority ethnic (BAME) groups.

Cardiovascular disease and type 2 diabetes are major causes for morbidity and mortality in the UK, particularly in black, Asian, and minority ethnic individuals (BAME). Impaired endothelial dysfunction created by aggravated inflammation [1, 2], underpins the metabolic syndrome experienced by these individuals.

Pharmacological interventions and changes in lifestyle habits early on in life have demonstrated an impact in the onset of the cardiovascular disease by targeting inflammation and improving vascular function, delaying the development of these diseases [3]. Research strongly suggests that exercise is pivotal in improving vascular function and cardiovascular morbidity, one mechanism purported to be through a reduction in inflammation [4].

However, despite continued advances in medicine, individuals from BAME populations continue to remain most at risk [5]. Preliminary research from our laboratory has highlighted cardiometabolic differences between South Asian and white European men in relation to their physical activity/exercise [6].

This project aims to extend this previous work studying the effects of exercise in BAME individuals and investigate the relationship with inflammation and biomarkers of vascular function.

The project will provide expertise in a range of techniques that will assess the impact of exercise and a range of physiological biomarkers that include biochemical and immunological techniques (e.g. ELISA, Clinical Chemistry, flow cytometry).

The research will be conducted in a multi-disciplinary team across the Faculty of Science, Engineering & Computing at Kingston University, as well as potential partner institutions/external collaborators. The exact programme of work will be established between the candidate and supervisory team following selection.

In addition, there may also be an opportunity to contribute to the group’s consultancy in exercise, nutrition and health, and public engagement programme.

Applicants should have a first or upper second class honours degree in a relevant area to the project. This includes human biology, physiology, biochemistry, sport science or nutrition. You will have excellent practical laboratory skills and excellent interpersonal skills for working with human volunteers. A Master’s degree or equivalent qualification or other evidence of research skills and experience is preferred but not essential.