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‘Exploitation of Influenza A virus’ reliance on host factors essential to virus entry to examine novel methods of virus attenuation for the generation of live attenuated vaccines’

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  • Full or part time
    Dr Yohei Yamauchi
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

PhD studentship (reference PhD_VIR_NIBSC)

A 3-year full-time PhD studentship is available at the Division of Virology, National Institute for Biological Standards and Control (NIBSC), in collaboration with the University of Bristol. The studentship is anticipated to commence on 1st October 2020.

Project Details
This PhD project will examine the importance of the interaction of the cell’s nuclear import machinery with the influenza A virus M1 protein. After gaining a fundamental understanding of the interaction, a combination of deep mutational scanning and influenza reverse genetics will be used to generate mutant influenza A viruses. These mutants will be assessed for their attenuation and possible use as novel live attenuated vaccine candidates.

NIBSC, a Centre of the Medicines and Healthcare products Regulatory Agency (MHRA), is a global leader in the characterisation, standardisation and control of biological medicines and has a major role in protecting and improving public health worldwide. NIBSC is the leading WHO International Laboratory for Biological Standardisation and is responsible for producing and distributing over 90% of all WHO International Standards introduced for the quality assurance of biological medicines. NIBSC scientists also test products, carry out valuable research and provide advice on a routine basis and in response to emergencies. The importance of the Institute’s work is well recognised nationally and internationally.

The Division of Virology delivers a wide range of internationally competitive activities in standardisation, control and underpinning research for virological matters relevant to biologicals for human use. The scope of work includes vaccines (particularly influenza, polio and childhood vaccines); emerging infections, including those identified as Priority Pathogens by the WHO; enteric viruses and neurovirology. The activities are underpinned by cutting-edge research by expert scientific staff.

The student will be registered with the School of Cellular and Molecular Medicine (CMM), in the Faculty of Life Sciences at the University of Bristol, where scientists work in an interdisciplinary environment equipped with state-of –the-art facilities such as the Wolfson Bioimaging facility, and are aiming at turning science into medicine.
The student will be supervised by Dr Jason Long (NIBSC), and co-supervised by Dr Othmar Engelhardt (NIBSC) and Dr Yohei Yamauchi (University of Bristol). The student will be based primarily at NIBSC with the opportunity for attendance at the University for additional training and work when required.

As a candidate you will be a motivated individual with a keen interest in undertaking research in the field of virology with a focus on influenza virus host-cell interactions, and how this knowledge can be exploited for the benefit of public health. You will have a 2:1 (or international equivalent) in a relevant subject; or a 2.2 (or international equivalent) and a master’s degree, both in a relevant subject.

For further details of the project, essential requirements for study and details how to apply, see https://www.nibsc.org/about_us/careers_and_vacancies/phd_studentships.aspx?

Closing date for applications: 5 pm (UK time), Friday, 27 March 2020.



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