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  Exploiting the microRNA ‘signature’ of high density lipoproteins in cells and tissues: routes to novel therapeutics (Ref: SHLS21096)

   School of Health and Life Sciences

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  Prof A Graham, Dr Gillian Hunter, Dr Steven Patterson  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The protective roles of high density lipoproteins (HDL) in inflammatory diseases (atherosclerosis, diabetes and impaired wound healing) has focused attention on the molecular mechanisms by which this heterogeneous lipoprotein class achieves these outcomes. In our recent studies, the global microRNA ‘signature’ associated with exposure to HDL has been analysed in divergent cell types. This posits a way of leveraging the therapeutic benefits of these lipoproteins, which have previously proved difficult to harness, due to the potentially unstable nature of these biologics. This studentship will investigate this hypothesis, using novel combinatorial approaches and bioinformatic analyses to highlight microRNA sequences targeting networks of genes implicated in disease conditions.  The successful candidate will have scope to refine and direct the nature of the research targets, providing productive collaborations within the research group, and across the School of Health and Life Sciences.

Professor Graham works in the field of cell and molecular biology, under the theme of Long Term Conditions (

The successful candidate will hold an upper second, or first class degree in an area related to biological sciences; previous experience of cell and molecular biology is desirable.

This project is available as a 3 years full-time PhD study programme.

 Candidates are encouraged to contact the research supervisors for the project before applying. 

 Applicants should apply for their preferred intake date using the Biological Sciences links via the Application Process page.   

Biological Sciences (4)

Funding Notes

Applicants are expected to find external funding sources to cover the tuition fees and living expenses. Alumni and International students new to GCU who are self-funding are eligible for fee discounts.
Bench fee of £5000 per annum are also applicable to this study
For further details please see our Fees and Funding and Research Scholarships and Studentships webpages.


Name: Ann Graham
GCU Research Online URL:
Name: Gillian Hunter
GCU Research Online URL:
Name: Steven Patterson
GCU Research Online URL:
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