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Exploring DDT metabolism in Tetrahymena thermophila

   School of Applied Sciences

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  Dr Hazel Girvan  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Studies of pesticide contaminated water sites have revealed the ability of Tetrahymena thermophila to metabolise Dichlorodiphenyltrichloroethane (DDT) with knockdown studies and microarray data suggesting a number of enzymes responsible for this metabolism; these enzymes will be the focus of this PhD project. Initial studies will focus around 5 candidate proteins; 3 cytochromes P450, 2 oxidoreductase redox partners and a short chain dehydrogenase. Studying these enzymes recombinantly will build an understanding of their function, mechanism and structure allowing us to begin to explore the potential for bioremediation or as a biomarker with a PhD student gaining skills as a protein biochemist, in enzymology, analytical chemistry and in structural biology. 

Funding Notes

The studentships are open to citizens of the UK and cover the full cost of tuition fees and an annual tax-free bursary of £16,062 for three years (RCUK rates). Successful applicants should have a first or upper second undergraduate degree or Masters degree in a relevant subject.
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