About the Project
We have recently discovered 12 transcriptional regulators that are associated with drug resistance in A. fumigatus. The functional role of many of these factors is unknown. In this project our aim is to use our extensive functional genomics toolkit, including tn-seq (a next generation sequencing approach to identify drug sensitive mutants), to fully characterise these transcriptional regulators, identify transcriptional co-regulators and identify routes to disrupting their function. The outputs of this project will support the development of novel diagnostics to detect antifungal resistance and help in the development of new antifungal drugs.
Training/techniques to be provided:
The student will benefit from a diverse and enriching environment and will be trained in the molecular manipulation and characterisation of the human pathogenic fungus Aspergillus fumigatus, molecular techniques including next generation sequencing and qPCR, in vitro assays including MIC determination, mammalian cell culture and in vivo animal models. These skills will provide the student with a competitive advantage for future professional job applications both to academia and industry.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in fungal biology or with an interest in anti-microbial resistance and pathobiology are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
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