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Exploring multi-herbicide resistance in black grass

  • Full or part time
  • Application Deadline
    Friday, January 11, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The global demand for safe and sustainable food production is constantly rising due to global population growth coupled with the global success in fighting extreme poverty which in turn is leading to improved and changed diets. While global resources are limited, multiple herbicide resistance (MHR) in grass weeds, such as Black grass has emerged as a major threat to cereal production in the UK and beyond. Recently, the phi-class glutathionine transferase (GSTF1) has been identified as the key player of non-target site resistance in Black-grass. In order to unravel the molecular mechanism of MHR we have solved the high-resolution crystals structure of AmGSTF1 (Pohl group), and in parallel developed a series of specific ligands (Steel groups). These compounds possess significant potential as molecular probes and as herbicide additives.

For further information see the website: https://www.dur.ac.uk/biosciences/

To apply

Please complete the online application form and attach a full CV and covering letter. Informal enquiries may be made to

Funding Notes

This is a 4 year BBSRC CASE studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,777 for 2018-19). The PhD will start in October 2019. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.

References

Tatum, N.J., Liebeschuetz, J.W., Cole, J.C., Frita, E., Herledan, A., Baulard, A.R., Willand, N., Pohl, E. (2017). New leads for Tuberculosis booster drugs by structure-based drug discovery. Org Biomol Chem 15:10245-255

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