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Exploring Sirtuins in cancer and ageing

School of Pharmacy and Bioengineering

About the Project

This post represents an exciting opportunity for an individual to undertake a PhD exploring sirtuins in cancer and ageing. Cancer and ageing are interconnected through inflammation.
Continuous exposure of internal and external stressors on cells can lead to a cancer diagnosis. Survival rates in cancer might be high, but many face devastating disabilities and long-term side effects resulting from current treatments.
Sirtuins (SIRT) regulate many key processes in cells, including their metabolism, health & death and shutting down genes that promote cancer growth, amongst their many roles. This family is key in modulating inflammation, cancer and ageing. In cancerous cells, SIRT’s activity can be compromised and modulation of it shows to produce anticancer activity. We are studying the
selective modulation of SIRT in cancerous and non-cancerous cells.
In this cell / molecular biology project, we will expand our knowledge on the modulation of the SIRT family with the aim of finding new targets downstream and producing new therapies. This is an exciting opportunity to identify new targets, we are looking to recruit a PhD student with a relevant biological, chemical or biomedical science background to study biological mechanisms
and new therapies to treat cancer.

This PhD is full time (3 years) and applications are open all year round.

Keele University values equality and diversity across our workforce and to ensuring our staff community is reflective of the diversity of our student population. In support of these commitments the University welcomes applications from individuals of Black, Asian and ethnic
minority backgrounds for all roles.

Funding Notes

Self funded students only.

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