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Exploring the cellular and molecular mechanism of bacterial probiotic action

  • Full or part time
  • Application Deadline
    Thursday, April 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

Six new fully funded PhD research studentships are offered in the School of Applied Sciences for a 23 September 2019 start. The School is made up of the Departments of Biological and Geographical Sciences, Chemical Sciences and Pharmaceutical Sciences.

There is competition funding for 6 of the 12 research projects advertised. Usually the projects which receive the best applicants are funded.

Successful applicants will receive a fully funded PhD opportunity for a cell or microbiologist to work on a project which will be focused on identifying and investigating the mechanism of action of the bioactive components of probiotic bacteria.
Whilst there is clinical evidence that supports the use of probiotics to alleviate the symptoms of important medical conditions ranging from intestinal disorders and cancers to mental health problems. There is little mechanistic data as to how intestinal bacteria such as probiotics achieved these effects.

This project will use the established expertise within the School of Applied Sciences to take a holistic approach to this research area. Specifically, microbiological, analytical chemistry and cell biological techniques will be brought together. This will allow different strains of intestinal bacteria to be grown and the bioactive molecules that they produce to be isolated, characterised and tested. Cell culture techniques will also be used to produce models of both the healthy and diseased intestine to investigate what effects specific products isolated from the bacteria have on both the innate and adaptive immune responses.

The use of in vitro models will allow the specific cellular pathways that mediate their biological effects to be studied in detailed. This will allow us not only to gain a better understanding of the mechanisms by which probiotic bacteria produce their beneficial effects it will also provide the potentially to use specific bacterial products medicinally.
The student will work with a group of scientist that have active research projects currently ongoing in all aspects of the project.

The studentships are open to citizens of the UK or EU only, and cover the full cost of tuition fees and an annual tax-free bursary of £15,009 for three years (RCUK rates). Successful applicants will have a very good first or upper second degree or Masters degree in a relevant subject. The course will begin in September 2019.

To apply, please send your CV and a personal statement to . Please indicate that you wish to apply for the project above and highlight Dr Andrew Collett, as the supervisor. Please note that the deadline for applications is 25 April 2019.
Please contact Dr Andrew Collett (), for enquiries on the project.

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