About the Project
The aim of the studentship is to examine how lymphatic vessels contribute to diabetic kidney disease and their potential as a therapeutic target. The student will (i) use three-dimensional imaging technologies to study the lymphatics of diabetic kidneys down to the detail of single cells; (ii) isolate cells from diabetic kidneys and perform single cell RNA sequencing to see how gene expression changes in lymphatics on a cell-by-cell basis, and how lymphatics might be interacting with other cells in the diseased kidney and (iii) target kidney lymphatics using gene therapy; delivering VEGF-C, a lymphatic growth factor, to the diabetic kidney. The project will utilise multiple techniques ranging from animal husbandry, three-dimensional imaging technologies, flow cytometry, single cell RNA-sequencing and gene therapy strategies. The PhD student will also obtain generic skills by attending relevant courses run by UCL.
For a full project description please see the GOS ICH website: https://www.ucl.ac.uk/child-health/phd-studentship-kidney-research
Applicants should have, or expect to receive an upper second-class Bachelor’s degree and a Master’s degree (or equivalent work experience) in a relevant discipline or an overseas qualification of an equivalent standard. The student will receive a starting stipend of £19,000 per annum (including London weighting) as well as the cost of tuition fees for UK/EU students (applicants from non-EU countries can apply but will have to personally fund the difference between the home/EU rate and the overseas rate).
To apply, please send a current CV including the contact details of two professional referees as well as a cover letter to [Email Address Removed].
Enquiries regarding the post can be made to Dr David Long ([Email Address Removed]).
Deadline for receipt of applications: 19th June 2020, 5pm
Interview date: TBC
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