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Exploring the fundamental molecular interactions modulating glycocalyx bioactivity

  • Full or part time
    Dr H Martinez-Seara Monne
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Glycocalyx or extracellular matrix is a charged thick layer of biomacromolecules, which is bound to the membrane at the cell surface. It is constituted fundamentally of polymeric-sugars, proteins, and the underlying membrane. Although the molecular structure of glycocalyx is directly responsible for many functions and pathologies, it is far from being understood. In this project, we have the ambitious goal of getting a more in-depth insight into the molecular interactions between fundamental components of the glycocalyx, e.i., sugar–sugar, sugar–protein, sugar–membrane. This project mainly focuses on computational methods(Molecular and Quantum mechanics). The students are also expected to do complementary experimental work, primarily spectroscopic methods (e.g., Raman, Fluorescence, and NMR) but also other physical chemistry technics (e.g., measurements of osmotic coefficients).

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Vuorio, J.; Vattulainen, I. & Martinez-Seara, H. Atomistic fingerprint of hyaluronan-CD44 binding. PLoS computational biology, 2017, 13, e1005663



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