About the Project
In this project, we aim to explore mechanisms of transport of particulate antigens from immunologically challenged mucosal sites to the spleen. Our goal is to define APC subsets that are able to reach the spleen from infected sites and to identify the mechanisms they use to enter and prime immune responses in the spleen. We will examine how certain types of stimuli that are often used in vaccine adjuvants may enhance or inhibit these events and we will determine the relevance of specific pathways to induction of protective immunity against influenza virus. The overall goal of the project is to understand the molecular basis of APC migration from the lung to the spleen and to explore the functional significance of these pathways during immunization.
Vaccine, spleen, adjuvant, influenza infection
In this project you will learn to combine advanced imaging techniques with a variety of immunological assays to interrogate the relationship between immune cell migration and function. The project is suitable for a student that is motivated by basic science and is excited about dissecting molecular mechanisms that regulate cell trafficking in vivo, using transgenic mouse models. Interested candidates are encouraged to contact Dr. Tal Arnon by email directly.
Gabriela Pirgova, Anne Chauveau, Andrew J MacLean, Jason G Cyster and Tal I Arnon. Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal centre B cells in the spleen. (2020) PNAS 18:201921673.
Andrea Reboldi, Tal I Arnon, Laura B Rodda, Atakilit A, Dean Sheppard and Jaons G Cyster. B cell interaction with subepithelial dendritic cells in Peyer's patches is critical for IgA production. (2016) Science 352(6287):aaf4822.
Tal I Arnon, Bob M Horton, Irina L Grigorova and Jason G Cyster. Visualization of splenic marginal zone B cell shuttling and follicular B cell egress. (2013) Nature 493(7434):684-8.
Emily E. Thornton, Mark R. Looney, Oishee Bose, Debasish Sen, Dean Sheppard, Richard Locksley, Xiaozhu Huang, Matthew F. Krummel. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. (2012) JEM 209 (6): 1183–1199.
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