About the Project
This project will investigate the interactions of muscle thick filament proteins and test how small molecules and mutations influence these interactions. The project will use a combination of molecular and structural biology, and biophysical methods, to fulfil these aims. These will include molecular cloning, protein expression and purification, electron microscopy, hydrogen-deuterium exchange mass spectrometry, computational modelling, and in silico-based drug design. Through this combination of structural biology and biophysical techniques, we can significantly improve our understanding of interactions within the muscle thick filament in health and disease. This work has the potential to lead to new therapeutic avenues for inherited heart disease. The candidate will benefit from working in a vibrant community of students and postdocs within structural and molecular biology, cardiovascular science, and biophysics.
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