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Exploring treatment resistance in mantle cell lymphoma


Project Description

The University of Plymouth’s Faculty of Health: Medicine, Dentistry & Human Sciences is seeking a highly motivated PhD candidate with outstanding abilities and enthusiasm for research. We are committed to research excellence with a recent £25 million investment in staff and facilities. Medical research in the Faculty was ranked first for outputs in REF2014. The PhD project will take place within an established research group that is linked to an active Clinical Trials Unit, which is nationally recognised for the treatment of mantle cell lymphoma, at University Hospitals Plymouth NHS trust.

Mantle cell lymphoma is a rare lymphoproliferative disorder for which drugs such as Bruton’s tyrosine kinase inhibitors are a highly effective treatment option. However resistance to these novel signal inhibitor drugs is seen highlighting the need for further understanding.

This exciting project works alongside a successful industry partner to explore mechanisms of resistance in fully characterised cell line models and primary mantle cell lymphoma cells. Building on previous work studies using mass spectrometry combined with protein knock down will explore potential biomarkers and mechanisms of resistance, which on further research could improve disease monitoring or identify pathways for therapeutic intervention.

Funding Notes

Funding Notes: The studentship is supported for 3 years and includes full Home/EU tuition fees, plus a stipend of an estimated £15,009 per annum (based on 19/20 stipend amounts). Applicants normally required to cover overseas fees will have to cover the difference between the Home/EU and the overseas tuition fee rates (£12,285 for the 19/20 academic year).

References

To Apply: Follow the link https://www.plymouth.ac.uk/student-life/your-studies/the-graduate-school/applicants-and-enquirers and click ‘Apply’. Please mark the application for the attention of Carole Watson. Please Note: You do not need to submit a project proposal with your application. If you have any questions on the admissions process contact [email protected]
The closing date for applications is 12 midnight on 27th October 2019.

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