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  Exploring Uncharted Territories: Investigating the Impact of Follicular Fluid Extracellular Vesicles on Spermatozoa Function


   School of Medicine and Population Health

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The intricate dynamics underlying successful mammalian reproduction continue to captivate scientific inquiry. However, the mechanisms governing the interaction between spermatozoa and the female reproductive tract remain elusive. This multifaceted interplay, orchestrating the journey to conception and the birth of a healthy offspring, operates at varying levels across species.

A novel and intriguing facet emerges in the form of Extracellular Vesicles (EVs) within the follicular fluid—a phenomenon that has caught the attention of our research group (https://doi.org/10.3390/biology10111154). These tiny lipid-bilayered vesicles, laden with an array of biomolecules, function as carriers of intercellular messages. Our group has uncovered a compelling link between EVs within the follicular fluid and their potential impact on spermatozoa function (https://doi.org/10.3390/biology10111154).

The present study aims to elucidate this phenomenon through the establishment of in vitro models simulating the interaction between follicular fluid EVs and spermatozoa. By dissecting these interactions, we endeavor to shed light on the intricate processes that may influence sperm function.

Our research group boasts extensive expertise across diverse domains, encompassing extracellular vesicles biology, reproductive medicine, as well as computational modeling. We harness state-of-the-art nanoparticle technologies, genomics, proteomics, and cutting-edge in silico modeling techniques in our pursuit of scientific advancement.

We invite applications from individuals who possess a strong command of the English language and an earnest enthusiasm for the intricacies of extracellular vesicles biology, reproductive physiology, and medicine. This opportunity presents a gateway to immerse oneself in the realm of reproductive science, contributing to the growing body of knowledge that could redefine our understanding of mammalian reproduction.

Entry Requirements:

Candidates must have a first or upper second class honors degree or significant research experience.

How to apply:

Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box (Professor Alireza Fazeli) and select School of Medicine & Population Health (Oncology and Metabolism) as the department.

Enquiries:

Interested candidates should in the first instance contact Professor Alireza Fazeli at  

Biological Sciences (4) Medicine (26)

Funding Notes

Open to self funded students only

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