Autoimmune diseases, including rheumatoid arthritis, type I diabetes and systemic lupus, affect up to 10% of the population with debilitating symptoms and a significant economic burden. There is an established role for immune cells called B cells in the development and progression of several autoimmune diseases, and B cell depletion therapies have produced promising results. For non-responding patients a potential therapeutic option is modulating B cell function, particularly of a subset of cells known as regulatory B cells. This project will examine the impact of extracellular vesicles, isolated from inflamed or resting conditions, on distinct B cell populations and disease progression in a murine model of type I diabetes.
The project involves in vivo models, high-parameter flow cytometry, proteomics, and gene expression analysis. It would be suited to an ambitious individual interested in immunology and autoimmunity.
English Language Requirements
Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required. *Taken within the last 2 years.
International students wishing to apply to Queen's University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes.
For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs.
If you need to improve your English language skills before you enter this degree programme, INTO Queen's University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this d
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