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FGF signalling in regulation of tumour immune microenvironment


   School of Medicine, Dentistry & Nursing

  Dr Tomoko Iwata  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Immune “cold” tumours are tumours with little infiltrations of T lymphocytes and therefore immune suppressed, developed by a mechanism of evasion from immune surveillance through cancer progression (Hallmarks of Cancer). They pose a challenge for therapy options, particularly for checkpoint inhibitors, which are otherwise promising in many cancer types. Bladder cancer is common, and one of the most highly mutated cancers, similar to lung cancer and melanoma. While potentially a preferred target of immunotherapy, the response is still limited. Recent molecular classification of muscle-invasive bladder cancer showed that FGFR3 overexpression was frequently observed in luminal-papillary subtype and non-T cell inflamed, immune cold tumours. Studies in our lab showed that activating FGFR3 mutation, frequently identified in bladder cancer, suppresses anti-tumour inflammation in the early stage of bladder tumour pathogenesis, thereby increasing overall frequency of tumorigenesis (1, 2). However, the mechanism of immune-suppression by FGFR3 in immune-cold subtype of bladder cancer is still unclear.

Myeloid cells, such as macrophages and neutrophils, could play anti- or pro-tumour roles depending on the stages of tumour progression. We hypothesized that sequence of signalling from myeloid cells to T cells may lead to overall immune suppression of the tumour. While suppression of anti-tumour inflammation may increase tumorigenesis, suppression of pro-tumour neutrophils may allow re-population of T cells in the tumour thereby sensitising tumours to immune checkpoint therapy. Suppression of neutrophils may also inhibit metastasis. Clinically, FGFR3 is one of the most important therapeutic targets in bladder cancer, and many drugs that target FGF signalling in cancers are already available (3). Therefore, a better understanding of the role of FGF signalling, and that of FGFR3, in regulation of tumour immune microenvironment will provide better opportunities for translation in bladder cancer and others.

In this project, the student will investigate the spatial relationship of FGF signalling and myeloid cells in the tumour immune microenvironment in tumour tissues, and evaluate the potentials of targeting FGF signalling and myeloid cells in improving effectiveness of immunotherapy.

The student will have opportunities to be trained in a variety of cutting-edge histopathology techniques and technologies, both lab-based and image analysis, including multispectral image analysis, special and quantitative digital pathology, immune and gene profiling, management of tissue resources of model and clinical specimens. 

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References

1. Foth M, Ahmad I, van Rhijn BW, van der Kwast T, Bergman AM, King L, et al. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. J Pathol. 2014;233(2):148-58.
2. Foth M, Ismail NFB, Kung JSC, Tomlinson D, Knowles MA, Eriksson P, et al. FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation. J Pathol. 2018;246(3):331-43.
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