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Fine mapping asthma-susceptibility loci to identify putative targets for drug development - Reference: T1/21


Department of Health Sciences

, Thursday, December 03, 2020 Competition Funded PhD Project (Students Worldwide)

About the Project

Asthma is a common chronic disease estimated to affect over 300 million individuals worldwide. There is a need for new medicines for asthma, particularly for severe, refractory disease where current medications are not effective. We have recently completed the largest genetic study of moderate-severe asthma and identified 25 genetic signals associated with greater risk of developing more severe asthma (1). The aim of this studentship is to understand the causal variation underlying these genetic signals to inform development of new asthma therapies. The project will involve cutting-edge computational genetics techniques to fine-map asthma susceptibility loci using recently released next-generation sequencing data for 200,000 subjects from UK Biobank and specific asthma cohorts. The mechanisms of action and translational potential of candidate causal variation will be investigated using state-of-the-art laboratory-based techniques in cells, tissue and samples from asthma patients. The student will be based within an internationally-recognised genetic epidemiology group with excellent training and development opportunities in genetics and statistics. During placements at the University of Nottingham and AstraZeneca, the student will gain experience of cutting-edge laboratory-based techniques and gain valuable insights into the drug development process and precision medicine. (1) Shrine N, et al. Lancet Respir Med. 2019 Jan;7(1):20-34.

Entry requirements

• Candidates applying to the 4-year PhD should hold or expect to hold a UK first-class or upper second-class (2:1) undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
• Candidates applying to the 1-year MSc + 4-year PhD should hold or expect to hold a first-class or upper second-class (2:1) undergraduate degree or overseas equivalent
• University of Leicester English language (URL: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs ) requirements apply
Candidates who do not meet these entry requirements, but feel they have additional research experience should describe this clearly in the applicant statement.
Applicants should note that this programme is not intended for clinically active, medically qualified candidates.

Eligibility

UK/EU and International* applicants may apply.
*International applicants not applying from a Low or Middle Income Country must be able to demonstrate that they can fund the difference between UK/EU and International tuition fees for the duration of the PhD.

Enquiries

For project enquiries please contact the relevant Theme lead or the project supervisor in the first instance.

Administration and general enquiries to Sarah Robinson at .

[[To Apply ]]
Please follow the application advice and submit your application using the online application form at
https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020

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