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Fine mapping asthma-susceptibility loci to identify putative targets for drug development (T1/2)

  • Full or part time
  • Application Deadline
    Thursday, December 05, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Asthma is a common chronic disease estimated to affect over 300 million individuals worldwide. There is a need for new medicines for asthma, particularly for severe, refractory disease where current medications are not effective. We have recently completed the largest genetic study of moderate-severe disease and identified 25 genetic signals associated with greater risk of developing more severe asthma (1).

This studentship aims to advance these findings in four ways; i) fine map each genomic region including the identification of structural variation using the recently released exon sequencing data for 50,000 subjects from UK Biobank and the identification of potential causative genes, ii) identify SNP markers of structural variation and complete a phenome-wide association study of each signal in UK Biobank to provide insight into the mechanistic nature of the association with asthma, iii) use SNP markers to investigate the association of signals with clinical and immunological features of asthma using UK Biobank and specific asthma cohorts, e.g. Genetics of Asthma Severity (GASP) N=5,500 and iv) for prioritised signals/genes identified in these analyses, initiate translational studies using cells, tissue and samples from asthma cohorts.

Entry Requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply.

This project is available for UK/EU/International students.

How to Apply

Application advice and application link:

https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020

Funding Notes

This project is funded by the Wellcome Trust Doctoral Training Programme.

Stipend for the PhD: Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997 (rates as of September 2019).

4 year PhD fee waiver at UK/EU rates.

International applicants need to ensure they can fund the difference between UK/EU and international fees for the duration of their studies.

We also will offer 2 fully funded places to international applicants from Lower-middle income countries per year. These will provide a full overseas fee waiver and stipend for 4 years.

References

(1) Shrine N, et al. Lancet Respir Med. 2019 Jan;7(1):20-34.

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