Birkbeck, University of London Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Reading Featured PhD Programmes

FOXA1 mutations in Lobular Breast Cancer: Reprogramming Responses to Tamoxifen

This project is no longer listed on and may not be available.

Click here to search for PhD studentship opportunities
  • Full or part time
    Prof D Heery
    Dr S Johnston
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Tumours of the breast are often hormone-dependent, meaning their growth is driven by steroid hormones such as estrogen. This hormone acts upon the estrogen receptor (ER), which together with other transcription factors such as FOXA1 drives tumour growth. While some patients respond well to hormone therapies such as Tamoxifen, others show a poor response. It is now clear there are different molecular subtypes of breast cancer that respond differently to hormone therapy. However, mechanisms of resistance are incompletely understood. The aim of this project is to investigate the mechanisms underlying the poor response to hormone therapies shown by patients with invasive lobular breast cancer (ILC), a subtype accounting for 10-15% of breast tumours that show a relatively high incidence of FOXA1 mutations.
The project will provide training in state of the art molecular techniques including identification of ER and FOXA1 regulated genes in ILC tumours and cell lines, and the effect of FOXA1 mutations on the assembly of complexes on target genes. The student will have opportunities to learn techniques such as CRISPR CAS9 genome editing of cell lines, RNA Seq, ChIP-Seq and/or RIME.

Environment & Supervision
The project will be jointly supervised by Prof. Heery (Pharmacy- Gene Regulation) and Dr Simon Johnston (Clinical Oncology).The majority of the project will be carried out within the Gene Regulation & RNA Biology Group within the Division of Biomolecular Sciences & Medicinal Chemistry, School of Pharmacy. The School of Pharmacy provides a vibrant cross-disciplinary research environment, with excellent support and training facilities for PG students.

Funding Notes

Applications are welcome from motivated students with Bachelors (2.1 or above) or Masters degree(s) in Science subjects. International applicants should visit our University pages for information regarding fees and funding at the University. Sponsored and self-funded students are particularly encouraged to contact us for further information ([Email Address Removed]) ([Email Address Removed])

Related Subjects

How good is research at University of Nottingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 44.10

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

FindAPhD. Copyright 2005-2019
All rights reserved.