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Fragment-Based Approach to Molecular Sensing

  • Full or part time
  • Application Deadline
    Sunday, March 10, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The Department of Chemistry at the University of Bath invites applications for a fully-funded PhD studentship commencing in September 2019.

Fragment-based approaches to finding novel small molecules that bind to proteins are well-established in drug discovery. The key concept is that weakly-binding small fragments form high-quality interactions that can be optimised into potent larger molecules with high binding affinities through linking, elaboration or merging strategies.
In this project, fragment-based drug discovery techniques will be applied to developing novel and robust reagents for applications in sensor development for biomarkers of disease. The focus will be on the design and synthesis of organic molecules with suitable sites for attaching to surfaces or biopolymers that can act as recognition elements in a portable healthcare device.

Applicants should hold, or expect to receive, a First Class or good Upper Second Class Honours degree in Chemistry, or the equivalent from an overseas university, and have a strong interest in Organic Chemistry. A master’s level qualification and/or relevant research experience would also be advantageous.

Informal enquiries are welcomed and should be directed to Professor Christopher Frost, .

Formal applications should be made via the University of Bath’s online application form for a PhD in Chemistry:

More information about applying for a PhD at Bath may be found here:

Anticipated start date: 30 September 2019.

Funding Notes

UK and EU students who have been resident in the UK since September 2016 will be considered for an EPSRC DTP studentship. Funding will cover UK/EU tuition fees, maintenance at the UKRI Doctoral Stipend rate (£15,009 per annum, 2019/20 rate) and a training support fee of £1,000 per annum for 3.5 years.

For more information on eligibility, see: View Website.

How good is research at University of Bath in Chemistry?

FTE Category A staff submitted: 33.10

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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