The Grey lab studies the role of protein homeostasis - so called "proteostasis - in healthy and malignant stem cells of the blood (haematopoeitic) system, with a particular focus on acute myeloid leukaemia (AML), a disease with very poor prognosis (Grey et al. 2020 & 2022).
This PhD studentship is aimed at understanding the fundamental biology of healthy and cancer stem cells in the blood system. Using a mixture of novel inducible mouse models, state-of-the-art culture systems and primary patient tissue, the student will study how the proteome of healthy and malignant cells of the haematopoietic system differ, and what therapeutic vulnerabilities exist. The student will be trained in a variety of haematology research techniques including; flow cytometry, small animal experimentation, stem cell growth and differentiation and stem cell niche engineering. This will be complimented by world-class proteomics facilities and high-throughput single cell analyses to develop a multifaceted project focussed on some of the most difficult questions that need addressing in AML.
The Grey lab is funded by the Medical Research Council, Leukaemia U.K., The Children's Cancer and Leukaemia Group and The Lady Tata Trust. We particularly encourage applicants from under-represented demographics and offer a supportive and energetic environment for students to develop and lead their project.
The Department of Biology at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.
The Department of Biology holds an Athena SWAN Gold Award. We are committed to supporting equality and diversity and strive to provide a positive working environment for all staff and students.
Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.
Programme: PhD in Biology (3 years)
Start date: 1st October 2023
Interviews: end of April 2023 on a date to be confirmed