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  Fully Funded MSc by Research in Cardiovascular and Diabetes Medicine: Activation of pro-resolution signalling via formyl peptide receptor 2 as a treatment for obesogenic pathologies.


   School of Medicine, Medical Sciences & Nutrition

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  Dr Dawn Thompson, Dr F Khan, Dr Alison McNeilly  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

The North-East Scotland (NES) Diabetes and Cardiovascular Research Alliance Masters Training Programme (MTP) in cardiovascular and diabetes medicine is an exciting new MTP that will expand interdisciplinary cardiovascular and diabetes research between the University of Aberdeen and the University of Dundee.

Activation of pro-resolution signalling via formyl peptide receptor 2 as a treatment for obesogenic pathologies.

Dr Dawn Thompson (University of Aberdeen)

Professor Faisel Khan (University of Dundee)

  • This study will test whether activation of formyl peptide 2 receptor, a GPCR essential for pro-resolution signalling, is beneficial in the treatment of Type 2 diabetes and cardiovascular disease, overlapping comorbidites associated with obesity.
  • The project will consist of in vitro (Western blotting, qPCR, ELISA) and in vivo (mouse models of obesity) experimentation to investigate the impact on the following;
  1. Insulin sensitivity and Type 2 diabetes.
  2. Endothelial function and atherosclerosis.
  • For further information on the project particulars, please contact the primary supervisor via the enquire now function below.

This opportunity to achieve an MSc by Research as part of this flagship collaborative programme between the two universities. Based either in Aberdeen or Dundee but with cross-institutional training opportunities, students will be embedded in vibrant multidisciplinary research teams with a mix of cardiovascular/diabetes clinicians and scientists. Excellent research training opportunities are provided, including MTP specific training events, and more general training and educational activities in the universities, highlighted for example by the newly established Doctoral Academy in Dundee.

ENTRY REQUIREMENTS

Applicants must possess or be expected to possess by the time of starting the MSc, at least one of the following:

  • First class, or upper second-class honours degree in a relevant scientific discipline, or equivalent
  • Postgraduate Masters degree in a relevant scientific discipline, or equivalent

APPLICATION PROCEDURE

Full application instructions and further information can be found here

Biological Sciences (4) Medicine (26)

Funding Notes

The start date for successful candidates will be February 2022. Funding and project duration is 1 year.
Full UK tuition fee covered. Stipend at UKRI rate (£15,609 p.a.)
International candidates can apply for this studentship but will have to find additional funding to cover the difference between overseas and home fees.
This opportunity is funded by the North-East Scotland Diabetes and Cardiovascular Research Alliance.
For full funding information please visit: abdn.ac.uk/mtp/csd

References

• Perretti M & Godson C (2020) Formyl peptide receptor type 2 agonists to kick-start
resolution pharmacology.Br J Pharmacol. 2020 Oct;177(20):4595-4600.
https://pubmed.ncbi.nlm.nih.gov/32954491/
• Garcia-Vaz E*, McNeilly AD *, Berglund LM, Gallagher JR, Dutius Andersson A-M,
McCrimmon RJ, Gomez MF and Khan F (2020) Inhibition of NFAT signalling restores
microvascular endothelial function in diabetes Diabetes.Mar;69(3):424-435.
https://pubmed.ncbi.nlm.nih.gov/31806622/
• Meakin P, Coull B, Tuharska Z, McCaffery C, Akoumianakis I, A Charalambos, Brown J, Griffin
KJ, Platt F, Ozber CH, Yuldasheva NY, Makava N, Skromna A, Prescott A, Siddiqui M, Palmer
CNS, Khan F, Ashford MLJ. (2020) Increased amyloid in obesity and diabetes causes vascular
dysfunction. J Clin Invest ; 130(8): 4104-4117. https://pubmed.ncbi.nlm.nih.gov/32407295

Where will I study?