Fully Funded MSc by Research in Cardiovascular and Diabetes Medicine: Defining insulin resistance in the brain and impact on cognition at University of Dundee on FindAPhD.com

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Prof Calum Sutherland, Prof Mirela Delibegovic No more applications being accepted Competition Funded PhD Project (UK Students Only)

Dundee United Kingdom Cardiology

School of Medicine, University of Dundee

About the Project

The North-East Scotland (NES) Diabetes and Cardiovascular Research Alliance Masters Training Programme (MTP) in cardiovascular and diabetes medicine is an exciting new MTP that will expand interdisciplinary cardiovascular and diabetes research between the University of Aberdeen and the University of Dundee.

Defining insulin resistance in the brain and impact on cognition

Dr Calum Sutherland

Prof Mirela Delibegovic

It is known that there is a relationship between diabetes, nutrition, cognitive function and neurodegenerative disorders e.g. dementia and Alzheimer’s disease. This Masters by research project will examine how dysregulation of the insulin signalling pathway in the brain can contribute to neurodegenerative disorders. The student will use a range of cell culture models including primary neuronal cultures, neuronal cell lines as well as in vivo preclinical models to delineate which actions of insulin on the brain contribute to both, metabolic and neurodegenerative disorders.

This opportunity to achieve a MSc by Research as part of this flagship collaborative programme between the two universities. Based either in Aberdeen or Dundee but with cross-institutional training opportunities, students will be embedded in vibrant multidisciplinary research teams with a mix of cardiovascular/diabetes clinicians and scientists. Excellent research training opportunities are provided, including MTP specific training events, and more general training and educational activities in the universities, highlighted for example by the newly established Doctoral Academy in Dundee.

ENTRY REQUIREMENTS

Applicants must possess or be expected to possess by the time of starting the MSc, at least one of the following:

First class, or upper second-class honours degree in a relevant scientific discipline, or equivalent
Postgraduate Masters degree in a relevant scientific discipline, or equivalent

APPLICATION PROCEDURE

Full application instructions and further information can be found here

Funding Notes

The start date for successful candidates will be October 2022. Funding and project duration is 1 year.

Full UK tuition fee covered. Stipend at UKRI rate (£16,062 p.a.)

This opportunity is funded by the North-East Scotland Diabetes and Cardiovascular Research Alliance.

For full funding information please visit: View Website

References

1) Souza Matos, M., Platt, B., & Delibegović, M. (2021). Effects of dietary restriction on
metabolic and cognitive health. Proceedings of the Nutrition Society, 80(2), 126-138.
doi:10.1017/S0029665120007910
2) Dekeryte R, Hull C, Plucińska K, Khan S, Kamli-Salino S, Mody N, Morrice N, McLaughlin C,
Gault V, Platt B, Delibegovic M. (2019) Effects of Liraglutide and Fenretinide treatments
on the diabetic phenotype of neuronal human BACE1 knock-in mice. Biochem Pharmacol.
166:222-230. doi: 10.1016/j.bcp.2019.05.020.
3) Morrice, N., van Aalten, L., McNeilly, A. et al. (2020) Reducing Glut2 throughout the body
does not result in cognitive behaviour differences in aged male mice. BMC Res Notes 13,
438. doi: 10.1186/s13104-020-05276-y

Where will I study?

University of Dundee

The University of Dundee brings together some of the best researchers in the world, developing ideas that positively impact the physical, social and psychological wellbeing of people and their communities, the economy, and the environment.