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Fully Funded MSc by Research in Cardiovascular and Diabetes Medicine: Role of hyaluronan receptor, RHAMM in metabolic regulation in obesity


   School of Medicine

  Dr L Kang, Prof G Nixon  Thursday, June 30, 2022  Competition Funded PhD Project (UK Students Only)

About the Project

The North-East Scotland (NES) Diabetes and Cardiovascular Research Alliance Masters Training Programme (MTP) in cardiovascular and diabetes medicine is an exciting new MTP that will expand interdisciplinary cardiovascular and diabetes research between the University of Aberdeen and the University of Dundee

Role of hyaluronan receptor, RHAMM in metabolic regulation in obesity 

Dr Li Kang (University of Dundee) 

Professor Graeme Nixon (University of Aberdeen) 

  • Obesity-associated insulin resistance is linked to increased deposition of extracellular matrix (ECM) components, such as collagens and hyaluronan in adipose tissue. 
  • The ECM activates membrane receptor signalling, which has been implicated in insulin resistance and inflammation in obesity. 
  • Using the state-of-the-art mouse transgenesis and in vivo mouse metabolic phenotyping techniques, this project will investigate the role of hyaluronan receptor, RHAMM in metabolic regulation during obesity. 
  • For further information on the project particulars, please contact the primary supervisor via the enquire now function below. 

This opportunity to achieve a MSc by Research as part of this flagship collaborative programme between the two universities. Based either in Aberdeen or Dundee but with cross-institutional training opportunities, students will be embedded in vibrant multidisciplinary research teams with a mix of cardiovascular/diabetes clinicians and scientists. Excellent research training opportunities are provided, including MTP specific training events, and more general training and educational activities in the universities, highlighted for example by the newly established Doctoral Academy in Dundee. 

ENTRY REQUIREMENTS 

Applicants must possess or be expected to possess by the time of starting the MSc, at least one of the following: 

  • First class, or upper second-class honours degree in a relevant scientific discipline, or equivalent 
  • Postgraduate Masters degree in a relevant scientific discipline, or equivalent 

APPLICATION PROCEDURE 

  • Full application instructions and further information can be found here 

Funding Notes

The start date for successful candidates will be October 2022. Funding and project duration is 1 year.
Full UK tuition fee covered. Stipend at UKRI rate (£16,062 p.a.)
This opportunity is funded by the North-East Scotland Diabetes and Cardiovascular Research Alliance.
For full funding information please visit:  View Website

References

1) Bugler-Lamb AR, Hasib A, Weng X, Hennayake CK, Lin C, McCrimmon RJ, Stimson RH,
Ashford MLJ, Wasserman DH, Kang L. Adipocyte integrin-linked kinase plays a key role in
the development of diet-induced adipose insulin resistance in male mice. Mol Metab
2021; 49:101197
2) Weng X, Lin D, Huang JTJ, Stimson RH, Wasserman DH, Kang L. Collagen 24α1 is increased
in insulin-resistant skeletal muscle and adipose tissue. Int J Mol Sci 2020; 21(16):E5738
3) Hasib A, Hennayake CK, Bracy DP, Bugler-Lamb AR, Lantier L, Khan F, Ashford MLJ,
McCrimmon RJ, Wasserman DH, Kang L. CD44 contributes to high-fat diet induced insulin
resistance in skeletal muscle of C57BL/6 mice. Am J Physiol Endocrinol Metab 2019;
317(6):E973-E983
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