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FULLY FUNDED PHD - Industrial Partnership PhD: Programming nano-particle adjuvants to manipulate the immune response of vaccine candidates

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  • Full or part time
    Prof J Brewer
    Prof P Garside
    Dr Donatello Laera
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

TO APPLY, CLICK ’VISIT WEBSITE’

Due to their limited immunogenicity, many vaccine antigens require formulation with an adjuvant.

The most common adjuvants in human and veterinary vaccination are aluminum salts (alum) which exist as aggregate particles ranging in size from 1 to ~20 µm.

Despite their long term use in vaccines, little is known regarding which physical parameters of Alum affect the immunological response and how these effects are mediated.

In vitro and in vivo evidence suggests that reducing the particle size of alum may improve the immune profile of alum adjuvants.

This PhD project aims to evaluate nano-sized alum formulations (aluminium salts) as an innovative adjuvant to interrogate the immune response against protein-based vaccines.

To achieve these goals, the PhD student will first work at GSK Siena with supervisor Dr Laera, to produce nano-sized alum suspensions and perform in vitro characterization of vaccine formulations.

The most promising nano-sized suspension(s) will be used to develop stable formulations and the student will then perform in vivo characterization in Glasgow (supervisors Profs Brewer and Garside) using their expertise in intravital imaging and in vivo immunological approaches

The successful student will be trained in formulation and characterisation of vaccines as well as state of the art in vivo immunology, experiencing both industrial and academic research environments.

Funding Notes

START DATE: 14th Sept 2020

This project is funded through the Industrial Partnership PhD scheme jointly by GSK and University of Glasgow.

The candidate MUST have a BSc(Hons) or MSc in a related subject and experience in either immunology or pharmaceutical formulation or related disciplines.

Preference will be given to candidates who can start within 6 months of interview.


Student stipend starts at £17,009
Fees for EU/UK students are included.

TO APPLY CLICK 'VISIT WEBSITE'

Related Subjects

How good is research at University of Glasgow in Clinical Medicine?

FTE Category A staff submitted: 177.40

Research output data provided by the Research Excellence Framework (REF)

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