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FULLY FUNDED PhD: Investigating epigenetic suppression of anti-inflammatory metabolic pathways in the rheumatoid myeloid compartment


College of Medicine, Veterinary and Life Sciences

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Prof C Goodyear , Prof M Barrett , Dr M Kurowska-Stolarska , Prof Kim Midwood No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

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Applications are invited for a four-year full time PhD studentship within The Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), starting October 2020.

This studentship is focused on the recognition of endogenous damage-associated molecules by the myeloid compartment and how this contributes to the perpetuation of chronic pathogenesis in rheumatoid arthritis.

Recent data has revealed that tenascin-C (an endogenous damage-associated molecule) drives a specific inflammatory metabolic cascade, which does not subsequently lead to an anti-inflammatory/resolution state.

Furthermore, the normal physiological pathways that drive the anti-inflammatory/resolution state are epigenetically dysregulated in rheumatoid arthritis.

In this project the student will elucidate why tenascin-C only drives a chronic inflammatory pathway and how this can be potentially be modulated to treat patients.

To achieve this, a range of immunological, metabolomic and molecular/epigenetic assays will be utilised. The student and the project will be primarily based in Glasgow, however, specific aspects of the project will be undertaken in Oxford.

This project is part of the RACE programme http://www.race-gbn.org/phds/.

RACE is a collaboration between the Universities of Birmingham, Glasgow, Newcastle and Oxford, with funding and support from Versus Arthritis.

The programme capitalises on the expertise of the contributing academic institutions, and offers an outstanding opportunity for students to undertake excellent project-based research training within world-class research environments.

Applicants will normally be expected to reside (or have residency) within the UK/EU. Applicants should have obtained, or expect to obtain a 2:1 or 1st Class Honours degree in a relevant subject.

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Funding Notes

Support includes an annual stipend at RCUK rates for 4 years, PhD registration fees at UK/EU student rate, research expenses and travel costs.


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