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Fully-funded PhD Studentship in High throughput technologies for the efficient downstream processing of recombinant proteins for production of low-cost rapid diagnostic kits - HiTECENDROPIK

  • Full or part time
  • Application Deadline
    Friday, April 12, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

In spite of substantial progress in the development of sophisticated methodologies for disease detection, they are often difficult to apply at the point of need, and some can also be time-consuming and/or expensive. There is therefore an increasing demand for the development of cheap and reliable antibody-based diagnostic tests (e.g. lateral flow kits) that can be used for simple, early-stage detection of a range of important diseases. Central to the ability to fabricate such kits is a system for efficient, low cost antibody and antigen production to defined specifications at an industrial scale.

This project main objectives are to develop new low-cost processes for recovery of recombinant proteins from bacteria vectors by using new approaches to cell lysis and membrane-based purifications.

The project will be carried out in the research labs of three main partners: Mologic (for 14 months in total, two months at the beginning and the rest 12 months after the 36th month), Engineering Department (ED) and Lancaster Environment Centre (LEC) at Lancaster University (the rest 34 months), under the supervision of scientists from different backgrounds (molecular biologist, protein biochemist, bio-process engineer and biotechnologist). This interdisciplinary PhD will provide unique skills to the candidate, who will be trained in molecular biology/protein biochemistry (protein expression in E. coli), membrane separations and bio-process design (cell lysis, protein membrane separation and cost analysis).
The programme is of key industrial relevance, as it will provide evidence that could be used as a first step to evaluate new alternative systems for commercial purification of recombinant proteins at reduced cost.

Entry requirements:
Candidates for this position should have or expect to achieve a first-class or upper second class degree in chemical engineering, chemistry, biochemistry or a closely related discipline. Experience in membrane separation processes, protein expression in microorganisms, protein purification and recovery, and analytical methods (electrophoresis, HPLC, UV-Vis spectroscopy etc) would be an advantage. Due to funding regulations applications are restricted to UK nationals or EU citizens that have lived in the UK for the last three years. Excellent communication and English writing skills will be required.

The studentship will start in October 2019. Early applications are strongly encouraged.

How to apply:
Formal applications should be made via the Lancaster University Postgraduate Admissions Portal. Once you have created an account you will be able to fill in your personal details, background and upload supporting documentation. However, it is recommended to notify Dr Papaioannou beforehand of your interest in this position to help ensure timely consideration of your application.
Lancaster University – ensuring equality of opportunity and celebrating diversity.

Funding Notes

The scholarship provides a stipend for its entire duration and covers the University tuition fees at Home/EU level, therefore it is only valid for UK based applicants.

How good is research at Lancaster University in General Engineering?

FTE Category A staff submitted: 24.98

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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