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Fully funded PhD studentship - Misprogramming of mesenchymal progenitor cells in human lung fibrosis

  • Full or part time
    Dr M Jones
  • Application Deadline
    Friday, April 26, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

Lead Institute / Faculty: Faculty of Medicine

Main Supervisor: Dr Mark Jones

Other members of the supervisory team: Prof Donna Davies, Dr Yihua Wang, Dr Rob Ewing

Duration of the award: 4 years, full time

Project description:

With an ageing population, fibrotic diseases are a major cause of morbidity and mortality worldwide, and treatment options are limited. In the Lung Fibrosis Group at the University of Southampton we aim to develop new ways to treat patients with idiopathic pulmonary fibrosis (IPF), a devastating disease with a prognosis as worse than many cancers (Jones, Lancet, 2017;389:1941-52). Healthy tissue is replaced by scar tissue, and lung architecture destroyed, preventing gas-exchange, and ultimately leading to respiratory failure and death.

We have recently shown that lung tissue in IPF is stiffer as a result of changes to individual collagen fibril architecture, identifying that increased ‘bone’ type collagen cross-links are a key determinant of progressive lung fibrosis (Jones, eLife 2018;7:e36354). This studentship will investigate the hypothesis that misprogramming of mesenchymal progenitor cells plays a key role in this fibrotic process.

The studentship will provide excellent wide-ranging training in state-of-the-art methodologies including advanced 3D cell culture, molecular biology, proteomics, and computational analysis of large datasets. You will perform mechanistic studies using gene editing and small molecule inhibitor approaches, investigating functional consequences on tissue stiffness within a tissue-engineered model of fibrosis. Additionally, with our collaborator Prof. Philipp Thurner there is the opportunity for a 1 month placement at Vienna University of Technology, Austria to gain understanding of biomechanical testing techniques at the nano- and micro-scale, so providing valuable international and inter-disciplinary experience.

The student will follow the 4 year integrated PhD programme (Immunity and infection pathway). https://www.southampton.ac.uk/medicine/postgraduate/research_degrees/degrees/phd_biomed_immunity.page

Doctoral Person Specification can be found at https://www.southampton.ac.uk/medicine/postgraduate/research_degrees/degrees/phd_biomed_immunity.page

Please contact: Informal enquiries may be addressed to Dr Mark Jones ()

Person Specification: See below
The successful candidate is likely to have the following qualifications:
• A 1st or 2:1 degree in a relevant discipline and/or second degree with a related Masters

Administrative contact and how to apply:
Please complete the University’s online application form, which you can find at
https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=7225&majr=7227&term=201920

Closing date: 26th April
Interview date: Week commencing 6th May.

Funding Notes

This prestigious Holgate Studentship is fully funded by the AAIR Charity, including fees (UK/EU), stipend and project costs. Eligible students will be paid at the standard UK Research Council recommended rate; for 2019/20 this is £15,009 pa.



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