About the Project
The projects will take advantage of the well characterised light manipulation that control the avian photoperiodic response. Using a series of photoperiod- and hormone-manipulations, the projects will investigate the hypothalamic-pituitary-gonadal regulation of seasonal rhythms in reproduction.
The main objectives are to characterize the photoperiodic regulation of transcriptomic and methylome plasticity in discrete nuclei and cell populations.
The PhD studentship will use cutting-edge Nanopore sequencing techniques to identify seasonal rhythms in epigenomic and transcriptomic patterns across the neuroendocrine-pituitary-gonad axis.
In order to examine the functional role of candidate genomic loci, projects will incorporate crispr-cas9 tools to gain control over tissue-specific transcript expression levels.
The student will learn several common methods in molecular biology (e.g. qPCR), hormone assays (e.g. ELISA), stereology, metabolic analyses and behavioural assessment.
The student will obtain a Home Office Personal Licence for animal research and formal training in Oxford Nanopore Sequencing and Crispr-cas9 design.
The student will also receive directed training in animal behaviour, stereotaxic injections, hormone measurement, neuroanatomy, histochemistry, cell culture, bioinformatics, and statistical analyses.
Upon completion, the training would allow progression into a variety of post-doctoral positions within the biomedical sciences, bioinformatics or biotechnology industries.
All enquiries relating to the project and/or suitability should be directed to Dr Tyler Stevenson.
Stevenson TJ. 2018. Epigenetic regulation of biological rhythms: an evolutionary ancient molecular timer. Trends Genetics 34:90-100.
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