About the Project
Acute and recurrent urinary tract infections (UTI) cause devastating infections in both the young and the elderly.
Whilst several bacterial species are able to cause infection, uropathogenic E. coli (UPEC) are responsible for >80% of infections, efficiently attaching to and invading bladder urothelial cells.
As most symptoms result from efficient colonisation of the bladder and kidneys, treatments that could limit or prevent adhesion and replication of are attractive.
One approach that could reduce the current reliance on antibiotics is the development of an effective vaccine. However, it is not clear which bacterial antigens would offer the best targets.
This project aims to address these issues by undertaking fundamental research to understand how bacterial modify gene expression during UPEC infection of the bladder and kidney.
This project will combine conventional molecular approaches with in vivo imaging to allow us to unmask ‘silent’ but important antigens that drive pathogenesis.
The project is funded jointly between the University of Glasgow and GSK Vaccines (Siena, Italy) where the student will be offered the opportunity of a 3 month industrial placement.
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