FULLY FUNDED PROJECT - Functional dissection of mitochondrial mutations in high grade serous ovarian cancer

   College of Medical, Veterinary and Life Sciences

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  Dr P Roxburgh, Dr Payam Gammage, Prof Colin Semple  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

'To apply, please click institution web link'*

There are 7500 new ovarian cancer cases in the UK per year making it the 6th most common cancer in females. Although ovarian cancer survival is improving, 5-year survival rates remain poor (42.6%).

The majority of ovarian cancer (OC) diagnosis are of the high-grade serous (HGS) type which despite initial sensitivity to platinum-based chemotherapy eventually disease becomes platinum resistant leading to death from ovarian cancer. To gain a more comprehensive understanding of HGSOC genomic complexity, in order to detect and manage it more effectively, ovarian cancer teams in Edinburgh and Glasgow (Gourley and Roxburgh) have collected a cohort of HGS tumours for WGS (n=115) and RNAseq (67). Combining these data with previously published data we have now produced the largest WGS HGSOC tumour cohort to date (N=324; matched RNA-seq N=204), generating new insights into the intersecting roles of mutations at different scales during tumourigenesis (Semple, Ewing). A major and novel finding from the analysis of this combined cohort is that mitochondrial mutational load in HGSOC confers a poorer patient survival.

*You must download and complete the below form with your application.

 CRUK_Scotland_Centre_recruitment form.docx

Biological Sciences (4)

Funding Notes

Applications are open to all individuals.
PhD studentship available to start in October 2023 for an outstanding applicant with a stipend of £21,000 p/a. This will be funded by the CRUK Scotland Centre, a joint initiative between the University of Edinburgh and the University of Glasgow.
Please note that applicants are not required to submit a research proposal when completing the online application. The CRUK EDI form is required for the process of application. please complete and upload on the Applicant Self-Service Portal.
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