FULLY FUNDED PROJECT - Functional dissection of mitochondrial mutations in high grade serous ovarian cancer


   College of Medical, Veterinary and Life Sciences

This project is no longer listed on FindAPhD.com and may not be available.

Click here to search FindAPhD.com for PhD studentship opportunities
  Dr P Roxburgh, Dr Payam Gammage, Prof Colin Semple  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

'To apply, please click institution web link'*

There are 7500 new ovarian cancer cases in the UK per year making it the 6th most common cancer in females. Although ovarian cancer survival is improving, 5-year survival rates remain poor (42.6%).

The majority of ovarian cancer (OC) diagnosis are of the high-grade serous (HGS) type which despite initial sensitivity to platinum-based chemotherapy eventually disease becomes platinum resistant leading to death from ovarian cancer. To gain a more comprehensive understanding of HGSOC genomic complexity, in order to detect and manage it more effectively, ovarian cancer teams in Edinburgh and Glasgow (Gourley and Roxburgh) have collected a cohort of HGS tumours for WGS (n=115) and RNAseq (67). Combining these data with previously published data we have now produced the largest WGS HGSOC tumour cohort to date (N=324; matched RNA-seq N=204), generating new insights into the intersecting roles of mutations at different scales during tumourigenesis (Semple, Ewing). A major and novel finding from the analysis of this combined cohort is that mitochondrial mutational load in HGSOC confers a poorer patient survival.

*You must download and complete the below form with your application.

 CRUK_Scotland_Centre_recruitment form.docx

Biological Sciences (4)

Funding Notes

Applications are open to all individuals.
PhD studentship available to start in October 2023 for an outstanding applicant with a stipend of £21,000 p/a. This will be funded by the CRUK Scotland Centre, a joint initiative between the University of Edinburgh and the University of Glasgow.
Please note that applicants are not required to submit a research proposal when completing the online application. The CRUK EDI form is required for the process of application. please complete and upload on the Applicant Self-Service Portal.
Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.