About the Project
In this PhD project, you will study the human DNA repair factor CtIP; an enigmatic protein playing an important role in the regulation of the resectosome which initiates the recombinational repair of double-stranded DNA breaks. It acts as a hub to integrate signalling cues and co‐ordinates the broken DNA with activity and recruitment of many other repair factors. Despite intense interest from both a
basic science and human disease perspective, we still have an exceptionally poor understanding of CtIP at the molecular level. The proposed PhD project will remedy this by building directly upon our recent breakthrough work.
Using an interdisciplinary combination of biochemical, biophysical and cell biological approaches you will study the interactions between CtIP, its partner proteins and broken DNA in order to provide new mechanistic insights into DSB repair regulation and the molecular basis for human disease including cancer.
Enquiries welcome to firstname.lastname@example.org
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