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Functional characterisation of DNA damage response deficiency in cancer

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  • Full or part time
    Dr A Wang
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.

Functional characterisation of DNA damage response deficiency in cancer

Project Description:
Genomic instability in cancer can arise as a consequence of mutations in the components of the DNA damage response (DDR) and has been postulated to be a common vulnerability of cancer cells that can lead to dependency of remaining functional DDR pathways for survival. The synthetic lethality concept, whereby simultaneous abrogation of two redundant pathways conferring lethality, offers a therapeutic approach for targeting these cancer cells with DDR gene mutations. The recent approval of PARP inhibitors for the treatment of cancer patients with mutation in BRCA genes demonstrates that the concept of synthetic lethality can be successfully exploited.
The application of synthetic lethality for targeting cancer cells showing broader DDR deficiencies requires a full understanding of the functional impact of the mutations and any potential adaptive mechanisms. The proposed research project will use a wide range of molecular and cell biology techniques to characterise and complement the functional impact of DDR gene mutations in cancer cells. Functional genomic and/or chemical screens will then be performed to identify novel adaptive mechanisms or suppressors of synthetic lethal interactions. The successful completion of the PhD project will identify clinically actionable synthetic lethal interactions and uncover novel drug targets for further development to suppress the adaptive rescue mechanisms.

Keywords /Subject Areas:
Cancer Therapy
Cancer biology
Genomic instability
DNA damage response

Funding Notes

Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world.
See icr.ac.uk/phds to apply
Applications close 11:55pm UK time on Sunday 17th November 2019

Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Biomedical Sciences.



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