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Click here to search FindAPhD.com for PhD studentship opportunitiesAbout the Project
This PhD project falls into the areas of supramolecular chemistry, chemical biology and DNA nanotechnology and involves the preparation and study of DNA-based materials and sensors. These systems vary from modified nucleic acids, in which DNA is tagged with redox-active or photo-active units, to completely artificial nucleic acids, in which the sugar-phosphate backbone of DNA is replaced entirely with metal-containing units. The student will study various characteristics of these systems, ranging from their spectroscopic and assembly-forming properties to their ability to mimic biological processes, such as DNA replication. Potential applications include sensing (e.g. for COVID-19, cancer or trauma) and the generation of DNA-based materials with novel catalytic, magnetic or conducting properties.
The student will be trained in the following techniques: organic synthesis; automated DNA synthesis; UV/vis, fluorescence & CD spectroscopy; electrochemistry; MS; HPLC; gel electrophoresis.
Funding Notes
Interested candidates should contact Prof Jim Tucker in the first instance by email, attaching an up-to-date CV.
References
2) Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA, JLHA Duprey, J. Carr-Smith, S. L. Horswell, J. Kowalski, JHR Tucker, J. Am. Chem. Soc., 2016, 138, 746-749. (http://pubs.acs.org/doi/abs/10.1021/jacs.5b11319)
3) Cisplatin Adducts of DNA as Precursors for Nanostructured Catalyst Materials, K Englert, R Hendi, PH Robbs, NV Rees, APG Robinson, JHR Tucker, Nanoscale Adv., 2020, 2, 4491-4497 (https://pubs.rsc.org/en/content/articlelanding/2020/na/d0na00528b#!divAbstract)
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