About the Project
The Carnegie School of Sport in partnership with Cranlea Human Performance Ltd are delighted to invite Masters by Research Applications for a project entitled ‘The effect of carbohydrate hydrogel supplementation on exogenous carbohydrate oxidation and gastrointestinal permeability at altitude’
Altitude induces deleterious effects on endurance performance in athletes, mountaineers and military personnel alike (Deb, et al., 2018). The use of carbohydrate supplementation during exercise as a nutritional strategy to enhance metabolic capability at altitude has received increasing attention (Margolis, et al., 2020; O’Hara, et al., 2017; Young, et al., 2018). However, several studies have demonstrated that oxidation of this exogenous carbohydrate source is suppressed at altitude (Margolis, et al., 2020; Young, et al., 2018), with subsequent negligible effects on performance (Bradbury, et al., 2020). Reasons for this are likely multifactorial, but the absorption of carbohydrate into the gut has been shown to be reduced in such conditions (Margolis, et al., 2020). Further, exercise at altitude has been revealed to induce gastrointestinal barrier permeability, which has been associated with a reduction in immunological capability post-exercise (Hill et al., 2020). Consuming a carbohydrate hydrogel supplement during exercise at altitude presents a novel strategy to mitigate these effects via increased gastric emptying, enhanced intestinal carbohydrate absorption, and the preservation of gastrointestinal barrier permeability.
Carnegie School of Sport and Cranlea Human Performance Ltd are delighted to offer one fully funded (fees only) Masters by Research (MRes) opportunity to evaluate the effect of carbohydrate hydrogel supplementation during exercise on exogenous glucose oxidation and gastrointestinal permeability at altitude.
This project provides an exciting opportunity to develop our existing research on carbohydrate metabolism at high altitude. The successful application will develop a variety of practical skills including phlebotomy, exercise testing within our brand-new state of the art normobaric hypoxic environmental chambers and will use 13C stable mass isotopes.
We are seeking a highly motivated student with an undergraduate degree (first or upper second class honours) in a related discipline, with a passion for environmental physiology / nutrition. Prior experience contributing to research projects and/or conducting exercise testing would also be desirable.
Applicants are encouraged to discuss their proposals and the project with the Project Lead, Professor John O’Hara at [Email Address Removed]
Applicants are asked to complete an application form and provide a proposal of the research to be undertaken using the criteria given below as a guide.
The proposal of the research can be up to three A4 pages in length (with references as an addition to the proposal) using type Arial 12 point.
Applicants should use the research project reference (Cranlea1) as the subject in the email subject line when submitting their applications.
The criteria listed below will also be used in both selecting those applicants who will be called for interview and those who will be successful in securing a studentship.
The three A4 pages must include:
a) Working Title
b) Qualifications, expertise and experience relevant to undertaking study for a Master of Research
c) Knowledge of the subject area that will ensure the development of a focused line of enquiry
d) Knowledge and understanding of research methods appropriate to undertaking a Master of Research in the area of research
e) Clarity on the original contribution that the completed Master of Research will make to the body of knowledge
f) Scale and scope of the proposed research in terms of delivery within the one-year study period
An application form is available by contacting [Email Address Removed] or [Email Address Removed]
The deadline for applications is midnight on 18th October 2020
References
Bradbury, K., Berryman, C., Wilson, M., Luippold, A., Kenefick, R., Young, A. and Pasiakos, S. (2020) Effects of carbohydrate supplementation on aerobic exercise performance during acute high altitude exposure and after 22 days of acclimatization and energy deficit. Journal of the International Society of Sports Nutrition, 17(4).
Deb, S., Brown, D., Gough, L., Mclellan, C., Swinton, P., Sparks, A. and Mcnaughton, L. (2018) Quantifying the effects of acute hypoxic exposure on exercise performance and capacity: A systematic review and meta-regression. European Journal of Sports Science, 18(2), pp. 243-256.
Hill, G. W., Gillum, T. L., Lee, B. J., Romano, P. A., Schall, Z. J., Hamilton, A. M., & Kuennen, M. R. (2020) Prolonged treadmill running in normobaric hypoxia causes gastrointestinal barrier permeability and elevates circulating levels of pro-and anti-inflammatory cytokines. Applied Physiology, Nutrition, and Metabolism, 45(4), pp. 376-386.
Margolis, L. M., Wilson, M. A., Whitney, C. C., Carrigan, C. T., Murphy, N. E., Radcliffe, P. N., Gwin, J. A., Church, D. D., Wolfe, R. R., Ferrando, A. A., Young, A. J. and Pasiakos, S. M. (2020) Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise. Metabolism Clinical and Experimental, 103.
O'Hara, J. P., Woods, D. R., Mellor, A., Boos, C., Gallagher, L., Tsakirides, C., Arjomandkhah, N. C., Holdsworth, D. A., Cooke, C. B., Morrison, D. J., Preston, T. and King, R. F. (2017) A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13c glucose and 13c fructose. Physiological Reports, 5(1). doi: 10.14814/phy2.13101.
Young, A., Berryman, C., Kenefick, R., Derosier, A., Margolis, L., Wilson, M., Carrigan, T., Murphy, N., Carbone, J., Rood, J. and Pasiakos, S. (2018) Altitude acclimatization alleviates the hypoxia-induced suppression of exogenous glucose oxidation during steady-state aerobic exercise. Frontiers in Physiology, 9.
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