The Hong Kong Polytechnic University Featured PhD Programmes
University College London Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Edinburgh Featured PhD Programmes
University of Leeds Featured PhD Programmes

Gene splicing in tissue morphogenesis (HAERTYE20DTP)

  • Full or part time
  • Application Deadline
    Monday, November 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Nearly all the genes in vertebrates undergo alternative splicing, the process through which different transcripts are generated from a single gene. Despite alternative splicing being common, tissue and developmental stage specific regulation of splicing, and the importance of this mechanism in fundamental biological processes remain little understood.

The aim of the project is to provide a novel understanding of the importance and regulation of alternative splicing in the ADAMTS gene family during development. ADAMTS (A Disintegrin and Metalloproteinase with /thrombospondin type I motifs) proteins are secreted enzymes with roles in tissue morphogenesis and many diseases. The student will use both computational and experimental approaches to annotate and functionally characterize transcripts through in-situ expression assays and gene manipulations in the model organism Xenopus.

We offer a highly collaborative PhD project between three research groups (Haerty: bioinformatics, Wheeler: cell and developmental biology, Edwards: developmental and cancer biology) combining computational biology and experimental developmental biology to investigate the diversity and function of alternatively spliced transcripts originating from genes of the ADAMTS family. The PhD student will gain expertise in computational biology, large datasets analysis, transcriptomics, long read sequencing technologies, genetics, microscopy and developmental biology.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website:

Funding Notes

For funding eligibility guidance, please visit our website: View Website. Full Studentships cover a stipend (2019/0 rate: £15,009pa), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

FindAPhD. Copyright 2005-2019
All rights reserved.