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Generation and characterisation of mouse models for venous and lymphatic malformations

  • Full or part time
  • Application Deadline
    Wednesday, May 01, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Vascular Development Laboratory (www.makinenlab.com) at Uppsala University aims to understand the regulation of the vasculature in physiological and pathological conditions. The lab develops and utilizes genetic mouse models in combination with a variety of molecular and cell biological approaches (including advanced microscopy, flow cytometry and (single cell) RNA sequencing) to study how endothelial cells communicate with the tissue environment to co-ordinate morphogenesis and functional specialisation of the vasculature. The lab also investigates how regulators of developmental (lymph)angiogenesis impact on genetic human diseases such as lymphoedema and vascular malformations.

The lab is part of a European MSCA-ITN network ‘V.A.Cure’ (www.vacure.eu) that aims to uncover core mechanisms underlying vascular anomalies and to leverage this information for extablishing novel therapeutic strategies. For this project, the lab invites applications for an Early Stage Researcher (ESR)/PhD student position (ESR4).

Job description

You will work on a research project with the following objectives:
• Generate mouse models for Pik3ca-driven venous and lymphatic malformation (VM/LM)
• Characterise the cellular mechanisms of lesion formation and progression in VM/LM mouse models using microscopy techniques
• Establish and utilise a method for detecting somatic/mosaic mutations at high sensitivity in biopsy samples to understand the contribution of mutant cells to human vascular lesions
• Test treatment strategies and study therapy responses in VM/LM mouse models
You will also take part in the international training programme of the network and participate in various networking and outreach events.

Requirements

We are looking for a motivated student with a strong commitment to basic and/or translational research, who:
• is eligible for MSCA-ETN funding, see Funding Notes.
• has a MSc degree in biology, biomedical sciences or related disciplines
• has experience with experimental research; in particular experience with in vivo work (including tissue dissection, preparation and staining), confocal microscopy and image processing and analysis would be advantageous
• has good skills in oral and written English
• is a team player with good communication skills

Appointment terms

The period of employment is 4 years. The successful candidate will receive an attractive salary in accordance with MSCA regulations for Early Stage Researchers for the first 3 years. The salary of the fourth year will be according to local guidelines at Uppsala University. Starting date: October 2019.

The successful candidate will devote most of the time towards his/her research level education. Other service activities within the department, e.g. education and administrative work can be included within the framework of the employment (maximum 20%).

How to apply

– Make sure you meet the qualifying requirements.
– The application must be submitted to Uppsala University via a web form that is accessible through this link:
https://www.uu.se/en/about-uu/join-us/details/?positionId=259517
Please also send your application to , mentioning the number of the ESR position (ESR4) in the subject line.
– Please include in the application:
• A motivation letter describing your research career goals, skills and experience (cover letter)
• Curriculum vitae
• Grade transcripts and BSc/MSc diploma (in English or with a translation into English)
• Two letters of recommendation or the contact information of at least 2 referees.

Deadline for submitting applications: 1 May 2019

More information

Please visit http://www.vacure.eu for more information on the project, the recruitment process and selection criteria. Further information on the activity of the research group can be accessed at http://www.makinenlab.com. Contact for questions:

Information about education at the postgraduate level, admission requirements and admission decisions can be found at http://www2.medfarm.uu.se/utbildning/forskarniva/vill_du_borja/

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Funding Notes

To be eligible for this H2020-MSCA-ITN funded PhD student position, you must:
– not have resided or carried out your main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account, and
– at the date of recruitment (=first day of employment), be in the first four years (full-time equivalent research experience) of your research career and not have been awarded a doctoral degree.

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