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Generation of MYB-NF1B translocation using CRISPR-Cas9 as a model for adenoid cystic carcinoma of the salivary gland


Project Description

Adenoid cystic carcinoma (ACC) of the salivary glands is characterised by slow growth, extensive perineurial invasion, frequent metastasis and low survival rates representing an area of high unmet medical need. Recent next generation sequencing studies have shown a low and diverse mutation rate in ACC with the only common genetic aberration being MYB-NFIB translocations, which are present in more than 50% of cases and are thought to be major drivers of ACC development. Molecular studies in ACC have been hampered by the lack of bona fide cell lines, particularly those containing MYB translocations. The aim of this studentship is to generate the MYB-NF1B translocation in cells of the salivary gland to establish and study models of ACC disease. The project involves the use of CRISPR/Cas9 technology on 3D salivary models (mini organs) derived from normal salivary gland cells.

Candidate profile

Candidates must have a first class or upper second class honours BA or BSc Honours/MSc or equivalent in Natural Sciences or Life Sciences

How to apply

Full details about these studentship projects, and the online application form, are available on our website, at: http://www.icr.ac.uk/phds Applications for all projects should be made online. Please ensure that you read and follow the application instructions very carefully.

Closing date: Monday 6th May 2019
Applicants should be available for interview end of May 2019.

Please apply via the ICR vacancies web portal
https://apply.icr.ac.uk/

Funding Notes

Full funding is available

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