We are looking for a talented and motivated recent graduate in Neuroscience, Biosciences or related discipline to engage in an exciting new project at Manchester Metropolitan University in collaboration with the Inherited Metabolic Diseases clinical team at the Royal Manchester Children’s Hospital (RMCH). The project is focused on better understanding the underlying mechanistic neurobiology of Gaucher’s disease, a rare childhood disease. This project will employ samples from Gaucher’s patients currently presenting at clinic at RMCH to address unmet clinical need by applying the principles of personalised medicine. You will generate induced pluripotent stem cell (iPSC) lines from patients and family members and specify these cells to neuronal and glial cell types for biochemical, genetic and molecular characterisation. This will involve the development of key skills in stem cell biology, long-read RNA sequencing, proteomics and molecular imaging. We anticipate that data generated in this studentship will contribute to the design of treatment strategies for Gaucher’s disease patients currently being treated on clinical trials and future advanced therapies.
The Centre for Bioscience at Manchester Met has recently benefitted from newly refurbished labs including a bespoke, stem cell culture lab. Furthermore, we have invested in new Nanopore sequencing, flow cytometry, calcium imaging, electrophysiology platforms and confocal microscopy within the last year making our labs state-of-the-art. The supervisorial team is made up of basic scientists at Manchester Met and clinical academics at RMCH meaning you will gain experience of bench to bedside research in this exciting and innovative project.
For more information visit https://www.mmu.ac.uk/research/research-study/scholarships#ai-71409-9