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Genetic and environmental factors conferring susceptibility to adverse respiratory impacts of air pollution - Reference: T23/23


Department of Health Sciences

About the Project

The impacts of air pollution are well recognised in terms of increased mortality but there is much less evidence available in terms of morbidity and potential modifying factors and surprisingly few studies on the impact on the lung. This study will examine the impacts of genetic, dietary and lifestyle factors that modify the known adverse impacts of air pollution on lung function using the large UK Biobank dataset. It will consider gene*environment interactions and also involve Mendelian randomisation analyses for further explore specific questions e.g. on role of diet in protecting against adverse effects of air pollution exposure. The study will provide a comprehensive assessment of factors that may help protect against adverse effects of air pollution on the lung, with particular focus on impact on deprivation and ethnicity. Findings will help inform potential for interventions such as improved diet in communities exposed to high air pollution.

Entry requirements

• Candidates applying to the 4-year PhD should hold or expect to hold a UK first-class or upper second-class (2:1) undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
• Candidates applying to the 1-year MSc + 4-year PhD should hold or expect to hold a first-class or upper second-class (2:1) undergraduate degree or overseas equivalent
• University of Leicester English language (URL: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs) requirements apply
Candidates who do not meet these entry requirements, but feel they have additional research experience should describe this clearly in the applicant statement.
Applicants should note that this programme is not intended for clinically active, medically qualified candidates.

Eligibility

UK/EU and International* applicants may apply.
*International applicants not applying from a Low or Middle Income Country must be able to demonstrate that they can fund the difference between UK/EU and International tuition fees for the duration of the PhD.

Enquiries

For project enquiries please contact the relevant Theme lead or the project supervisor in the first instance.

Administration and general enquiries to Sarah Robinson at .

To Apply

Please follow the application advice and submit your application using the online application form at
https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020

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