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Genetic and environmental factors conferring susceptibility to adverse respiratory impacts of air pollution

   Department of Health Sciences

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  Prof A Hansell, Prof F Dudbridge  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

Leicester United Kingdom Epidemiology Genetics Statistics

About the Project

Wellcome Trust Studentship


The impacts of air pollution are well recognised in terms of increased mortality but there is much less evidence available in terms of morbidity and potential modifying factors and surprisingly few studies on the impact on the lung. 

This study will examine the impacts of genetic, dietary and lifestyle factors that modify the known adverse impacts of air pollution on lung function using the large UK Biobank dataset. It will consider gene*environment interactions and also involve Mendelian randomisation analyses for further explore specific questions e.g. on role of diet in protecting against adverse effects of air pollution exposure. 

The study will provide a comprehensive assessment of factors that may help protect against adverse effects of air pollution on the lung, with particular focus on impact on deprivation and ethnicity. Findings will help inform potential for interventions such as improved diet in communities exposed to high air pollution.

Additional Information

  • Open to UK and International Students.
  • 4 year Competition Funded
  • Candidates applying to the 4-year PhD should hold or expect to hold an undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
  • Start date September 2022
  • Closing date for applications 11:59pm 1 December 2021.

For full details of the PhD Studentship, application advice and link to the application system please refer to https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust. CVs submitted via the enquiry form below will not be accepted.

Funding Notes

4 Year competition funding
• Postgraduate research fee waiver at standard College of Life Sciences UK rates for all four years of the PhD
• Wellcome Trust stipend for all four years of the PhD ( Wellcome Trust stipend rates: PhD Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997.)
• International students who are not from an identified LMIC are welcome to apply but may be required to pay the difference between home student fees and international student fees for the duration of their studies.
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